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清华大学生命学院

科研成果

生命学院代表性论文

  • Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.

    Zhongmin Liu, Jia Wang, Hang Cheng, Xin Ke, Lei Sun, Qiangfeng Cliff Zhang, HongWei Wang

    Cell 2018,173 (5): 1191-1203.

  • Chromatin analysis in human early development reveals epigenetic transition during ZGA.

    Jingyi Wu, Jiawei Xu, Bofeng Liu, Guidong Yao, Peizhe Wang, Zili Lin, Bo Huang, Xuepeng Wang, Tong Li, Senlin Shi, Nan Zhang, Fuyu Duan, Jia Ming, Xiangyang Zhang, Wenbin Niu, Wenyan Song, Haixia Jin, Yihong Guo, Shanjun Dai, Linli Hu, Lanlan Fang, Qiujun Wang, Yuanyuan Li, Wei Li, Jie Na, Wei Xie, Yingpu Sun.

    Nature 2018,557: 256–260.

  • Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation.

    Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei, Yigong Shi.

    Science 2018,360 (6396): 1423-1429.

  • Structure of the humanPKD1-PKD2 complex.

    Qiang Su, Feizhuo Hu, Xiaofei Ge, Jianlin Lei, Shengqiang Yu, Tingliang Wang, Qiang Zhou, Changlin Mei, Yigong Shi.

    Science 2018,361 (6406): eaat9819.

  • Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1.

    Xiaojing Pan, Zhangqiang Li, Qiang Zhou, Huaizong Shen, Kun Wu, Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan.

    Science 2018,362 (6412): eaau2486.

  • Structural basis for the modulation of voltage-gated sodium channels by animal toxins.

    Huaizong Shen, Zhangqiang Li, Yan Jiang, Xiaojing Pan, Jianping Wu, Ben Cristofori-Armstrong, Jennifer J. Smith, Yanni K.Y. Chin, Jianlin Lei, Qiang Zhou, Glenn F. King, Nieng Yan.

    Science 2018,362 (6412): eaau2596.

  • An autoimmune disease variant of IgG1 modulates B cell activation and differentiation.

    Xiangjun Chen, Xiaolin Sun, Wei Yang, Bing Yang, Xiaozhen Zhao, Shuting Chen, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang,Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan,Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li, Wanli Liu.

    Science 2018,362 (6415): 700-705.

  • Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates.

    Lu Yan, Jing Chen, Xuechen Zhu, Jiawei Sun, Xiaotong Wu, Weimin Shen, Weiying Zhang, Qinghua Tao, Anming Meng.

    Science 2018,362 (6417): eaat1045.

  • Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae

    Wan, Ruixue; Yan, Chuangye; Bai, Rui; Lei, Jianlin; Shi, Yigong

    CELL 2017,171(1):120-132.

  • Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae.

    Rui Bai, Chuangye Yan, Ruixue Wan, Jianlin Lei, Yigong Shi.

    CELL 2017,171(7):1589-1598.

  • Structure of mammalian respiratory supercomplex I1III2IV1.

    Wu, Meng; Gu, Jinke; Guo, Runyu; Huang, Yushen; Yang, Maojun.

    CELL 2016,167(6):1598-1609.

  • Structure of phycobilisome from the red alga Griffithsia pacifica

    Zhang, Jun; Ma, Jianfei; Liu, Desheng; Qin, Song; Sun, Shan; Zhao, Jindong; Sui, Sen-Fang

    NATURE 2017,551(7678):57-63.

  • A dicer-independent route for biogenesis of siRNAs that direct DNA methylation in Arabidopsis.

    Ye, Ruiqiang; Chen, Zulong; Lian, Bi; Rowley, M. Jordan; Xia, Ning; Chai, Jijie; Li, Yan; He, Xin-Jian; Wierzbicki, Andrzej T.; Qi, Yijun.

    MOLECULAR CELL 2016,61(2):222-235.

  • DWARF14 is a non-canonical hormone receptor for strigolactone.

    Yao, Ruifeng; Ming, Zhenhua; Yan, Liming; Li, Suhua; Wang, Fei; Ma, Sui; Yu, Caiting; Yang, Mai; Chen, Li; Chen, Linhai; Li, Yuwen; Yan, Chun; Miao, Di; Sun, Zhongyuan; Yan, Jianbin; Sun, Yuna; Wang, Lei; Chu, Jinfang; Fan, Shilong; He, Wei; Deng, Haiteng; Nan, Fajun; Li, Jiayang; Rao, Zihe; Lou, Zhiyong; Xie, Daoxin.

    NATURE 2016,536(7617):469-473.

  • HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage.

    Qian, Hui; Chen, Yuanying; Nian, Zongqian; Su, Lu; Yu, Haoyong; Chen, Feng jung; Zhang, Xiuqin; Xu, Wenyi; Zhou, Linkang; Liu, Jiaming; Yu, Jinhai; Yu, Luxin; Gao, Yan; Zhang, Hongchao; Zhang, Haihong; Zhao, Shimin; Yu, Li; Xiao, Ruiping; Bao, Yuqian; Hou, Shaocong; Li, Pingping; Li, Jiada; Deng, Haiteng; Jia, Weiping; Li, Peng.

    Journal of Clinical Investigation 2017,127(4):1353-1369.

  • BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.

    Qi, Zhen; Li, Yehua; Zhao, Bing; Xu, Chi; Liu, Yuan; Li, Haonan; Zhang, Bingjie; Wang, Xinquan; Yang, Xiao; Xie, Wei; Li, Baojie; Han, Jingdong Jackie; Chen, Yeguang.

    NATURE COMMUNICATIONS 2017,8:13824.

  • Kinesin 1 drives autolysosome tubulation.

    Du, Wanqing; Su, Qian Peter; Chen, Yang; Zhu, Yueyao; Jiang, Dong; Rong, Yueguang; Zhang, Senyan; Zhang, Yixiao; Ren, He; Zhang, Chuanmao; Wang, Xinquan; Gao, Ning; Wang, Yanfeng; Sun, Lingfei; Sun, Yujie; Yu, Li.

    DEVELOPMENTAL CELL 2016,37(4):326-336.

  • Allelic reprogramming of the histone modification H3K4me3 in early mammalian development.

    Zhang, Bingjie; Zheng, Hui; Huang, Bo; Li, Wenzhi; Xiang, Yunlong; Peng, Xu; Ming, Jia; Wu, Xiaotong; Zhang, Yu; Xu, Qianhua; Liu, Wenqiang; Kou, Xiaochen; Zhao, Yanhong; He, Wenteng; Li, Chong; Chen, Bo; Li, Yuanyuan; Wang, Qiujun; Ma, Jing; Yin, Qiangzong; Kee, Kehkooi; Meng, Anming; Gao, Shaorong; Xu, Feng; Na, Jie; Xie, Wei.

    NATURE 2016,537(7621):553-557

  • Next generation industrial biotechnology based on extremophilic bacteria.

    Chen, Guoqiang; Jiang, Xiaoran.

    CURRENT OPINION IN BIOTECHNOLOGY 2018,50:94-100.

  • A synthetic molecular system capable of mirror-image genetic replication and transcription. Nature Chemistry.

    Wang, Zimou; Xu, Weiliang; Liu, Lei; Zhu, Ting F.

    NATURE CHEMISTRY 2016,8(7):698-704.

  • Cdc42-dependent forgetting regulates repetition effect in prolonging memory retention.

    Zhang, Xuchen; Li, Qian; Wang, Lianzhang; Liu, Zhongjian; Zhong, Yi.

    CELL REPORTS 2016,16(3):817-825.

  • Near-atomic resolution structure determination in over-focus with Volta phase plate by CS-corrected cryo-EM.

    Fan, Xiao; Zhao, Lingyun; Liu, Chuan; Zhang, Jincan; Fan, Kelong; Yan, Xiyun; Peng, Hailin; Lei, Jianlin; Wang, Hongwei.

    STRUCTURE 2017,25(10):1623-1630.